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◎文/藥師楊佳蒨
其他一些中藥含有去甲烏藥鹼Higenamine,是目前最常在運動員尿液中被檢出的中藥興奮劑成分,廣泛存在於多種中藥材與食材,包括黃柏/黃蘗(Phellodendri
Cortex)、買麻藤(Gnetum montanum Markgr.)、南天竹(Nandina domestica Thunb.)、細辛(Asari
Radix)、川烏頭(Aconiti Radix)、漢防己(Stephaniae Tetrandrae Radix)、蓮(Nelumbinis)、釋迦(Annona
Squamosa L.)等,去甲烏藥鹼被歸類為S3類β2 受體致效劑(β2 -
agonists),而非S6興奮劑,但由於其具有腎上腺素作用(adrenergic
effect),因此常被提及並討論其興奮劑活性,代謝產物可在尿液中持續檢出數天,且部分濃縮製劑含量極高,服用後可導致尿液檢測陽性,運動員服用常規劑量即有違規風險。2,5,16,17,18,19
在亞洲(特別是中國、台灣、韓國)運動員中,因中藥材使用頻率高,去甲烏藥鹼、麻黃鹼、番木鼈鹼/士的寧等成分常因增強體能、恢復疲勞、減重等目的被誤用,陽性檢出率明顯高於歐美國家,各國需根據當地用藥習慣與政策調整檢測策略,以降低非故意違規風險。2,10,11,20
(全文完)
參考資料:
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18. Identification and Characterization of Higenamine Metabolites in
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19. Undeclared Doping Substances Are Highly Prevalent in Commercial
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(本文作者為彰化基督教醫院中醫藥局主任)
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