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®×¨Ò¡G¨ô¥ý¥Í ¦~ÄÖ¡G35·³ ¨°ª¡G172cm Åé«¡G135kg
µÇ¥\¯à¡GCreatinine=16.37 mg/dL, Clcr=12.03 ml/min, eGFR=3.4 ml/min/1.73m2
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1.Benzbromarone²¤¶
Benzbromarone¬O¤@ºØ§¿»Ä±Æªn¾¯¡A¥Î©óªvÀøµh·¬ÛÃöªº°ª§¿»Ä¦å¯g¡C¨ä§@¥Î¾÷¨î¬O³q¹L§í¨îµÇ¤pºÞ¹ï§¿»Äªº¦A§l¦¬¡A«P¶i§¿»Ä±Æªn¡A°§C¦å²G¤¤ªº§¿»Ä¿@«×¡C¤@¯ë¦¨¤H°_©l¾¯¶q¬°25~50mg
QD¡Aºû«ù¾¯¶q¬°50mg QD-TID¡AµÇ¥\¯à¤£¥þªÌeGFR >30 mL/min/1.73m2¤£»Ý½Õ¾ã¾¯¶q¡A¦ýeGFR
<30 mL/min/1.73m2ªÌ¤£«Øij¨Ï¥Î¡C¨x¥\¯à¤£¥þªÌ¤£«Øij¨Ï¥Î¡C¥t¥~¡ABenzbromarone¨ã¨x¥\¯à²§±`ªº°Æ§@¥Î¡A¦]¦¹¦b¨Ï¥Î®É»Ýn©w´ÁºÊ´úGPT¡BGOT¡B
Bilirubin¡BAlkaline phosphatase¡C
2.Febuxostat²¤¶
Febuxostat¬O¤@ºØ¿ï¾Ü©Êxanthine oxidase§í¨î¾¯¡A´î¤Ö§¿»Äªº¥Í¦¨¡A¶i¦Ó°§C¦å²G¤¤ªº§¿»Ä¿@«×¡A¥Î©óªvÀøµh·¬ÛÃöªº°ª§¿»Ä¦å¯g¡C¦bªvÀø¿@«×®É¤£·|§í¨î¦bpurine©Mpyrimidine¦X¦¨»P¥NÁ¹Lµ{¤¤¨ä¥L»Ã¯Àªº§@¥Î¡C¤@¯ë¦¨¤H°_©l¾¯¶q¬°40mg
QD¡AY¨Ï¥Î¨â¶g«á¦å¤¤§¿»ÄÈ¥¼¹F<6 mg/dL¡A¥i½Õ°ª¦Ü80mg QD¡CµÇ¥\¯à¤£¥þªÌCrCl <30 mL/min«Øij½Õ§C¾¯¶q¦Ü20~40mg
QD¡C¨Ï¥ÎÃĪ««e¤w¨x¥\¯à¤£¥þªÌ¡A¤£¶·½Õ¾ã¾¯¶q¡F¨Ï¥ÎÃĪ««áµo¥Í¨x¥\¯à²§±`¡GGPT/GOT >3¿¥¿±`ȤW¨Ã¥B¦³¨xª¢¯gª¬©ÎGPT/GOT
>3¿¥¿±`ȤW¦X¨ÖBilirubin >2¿¥¿±`ȤW¡A«Øij°±ÃÄ¡C
3.ºÃ¸q»¡©ú
¯f¤H¹L¥h¯f¥v¬°°ª¦åÀ£¡BºC©ÊµÇŦ¯f¡]CKD stage
3¡^¡B¼~Æ{¯g¡Bµh·Ãö¸`ª¢¥¼³W«hªAÃÄ¡C¦¹¦¸¦]¥k¤UªÏµL¤O»P³Â¤ì¤J«æ¶E¡A¦Ó«áµL¤O·P§ïµ½¡A¶EÂ_¬°µu¼È©Ê¯Ê¦å©Ê¸£¤¤·¤J°|¡C©â¦åÀËÅçÅã¥Ü«æ©ÊµÇ°IºÜ¥BÄY«¥NÁ»Ħå¯g»P°ª¦å¹[¡Aµ¹¤©¬~µÇªvÀø¡C¤J°|´Á¶¡¦]¥ª½ï¯kµh¡A¶EÂ_¬°µh·µo§@¥BUric
acid 11.3 mg/dL¡AÂå®vì¥ý¶}¥ßbenzbromarone 50mg QD¡A¦]¯f¤HµÇ¥\¯à®teGFR 3.4 mL/min/1.73m2¥B¤w¬~µÇ¡A¬G¤£«Øij¨Ï¥Î¡A½ÐÂå®v§ï¬°febuxostat
40mg QD¡C
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1.Benzbromarone: Drug information. UpToDate Lexidrug. Waltham, MA.
http://www.uptodate.com (Accessed on July 16, 2024.)
2.Febuxostat: Drug information. UpToDate. Waltham, MA.
http://www.uptodate.com (Accessed on July 16, 2024.)
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