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Benzbromarone vs. Febuxostat
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1.Benzbromarone²¤¶


Benzbromarone¬O¤@ºØ§¿»Ä±Æªn¾¯¡A¥Î©óªvÀøµh­·¬ÛÃöªº°ª§¿»Ä¦å¯g¡C¨ä§@¥Î¾÷¨î¬O³q¹L§í¨îµÇ¤pºÞ¹ï§¿»Äªº¦A§l¦¬¡A«P¶i§¿»Ä±Æªn¡A­°§C¦å²G¤¤ªº§¿»Ä¿@«×¡C¤@¯ë¦¨¤H°_©l¾¯¶q¬°25~50mg QD¡Aºû«ù¾¯¶q¬°50mg QD-TID¡AµÇ¥\¯à¤£¥þªÌeGFR >30 mL/min/1.73m2¤£»Ý½Õ¾ã¾¯¶q¡A¦ýeGFR <30 mL/min/1.73m2ªÌ¤£«Øij¨Ï¥Î¡C¨x¥\¯à¤£¥þªÌ¤£«Øij¨Ï¥Î¡C¥t¥~¡ABenzbromarone¨ã¨x¥\¯à²§±`ªº°Æ§@¥Î¡A¦]¦¹¦b¨Ï¥Î®É»Ý­n©w´ÁºÊ´úGPT¡BGOT¡B Bilirubin¡BAlkaline phosphatase¡C


2.Febuxostat²¤¶


Febuxostat¬O¤@ºØ¿ï¾Ü©Êxanthine oxidase§í¨î¾¯¡A´î¤Ö§¿»Äªº¥Í¦¨¡A¶i¦Ó­°§C¦å²G¤¤ªº§¿»Ä¿@«×¡A¥Î©óªvÀøµh­·¬ÛÃöªº°ª§¿»Ä¦å¯g¡C¦bªvÀø¿@«×®É¤£·|§í¨î¦bpurine©Mpyrimidine¦X¦¨»P¥NÁ¹Lµ{¤¤¨ä¥L»Ã¯Àªº§@¥Î¡C¤@¯ë¦¨¤H°_©l¾¯¶q¬°40mg QD¡A­Y¨Ï¥Î¨â¶g«á¦å¤¤§¿»Ä­È¥¼¹F<6 mg/dL¡A¥i½Õ°ª¦Ü80mg QD¡CµÇ¥\¯à¤£¥þªÌCrCl <30 mL/min«Øij½Õ§C¾¯¶q¦Ü20~40mg QD¡C¨Ï¥ÎÃĪ««e¤w¨x¥\¯à¤£¥þªÌ¡A¤£¶·½Õ¾ã¾¯¶q¡F¨Ï¥ÎÃĪ««áµo¥Í¨x¥\¯à²§±`¡GGPT/GOT >3­¿¥¿±`­È¤W­­¨Ã¥B¦³¨xª¢¯gª¬©ÎGPT/GOT >3­¿¥¿±`­È¤W­­¦X¨ÖBilirubin >2­¿¥¿±`­È¤W­­¡A«Øij°±ÃÄ¡C


3.ºÃ¸q»¡©ú


¯f¤H¹L¥h¯f¥v¬°°ª¦åÀ£¡BºC©ÊµÇŦ¯f¡]CKD stage 3¡^¡B¼~Æ{¯g¡Bµh­·Ãö¸`ª¢¥¼³W«hªAÃÄ¡C¦¹¦¸¦]¥k¤UªÏµL¤O»P³Â¤ì¤J«æ¶E¡A¦Ó«áµL¤O·P§ïµ½¡A¶EÂ_¬°µu¼È©Ê¯Ê¦å©Ê¸£¤¤­·¤J°|¡C©â¦åÀËÅçÅã¥Ü«æ©ÊµÇ°IºÜ¥BÄY­«¥NÁ»Ħå¯g»P°ª¦å¹[¡Aµ¹¤©¬~µÇªvÀø¡C¤J°|´Á¶¡¦]¥ª½ï¯kµh¡A¶EÂ_¬°µh­·µo§@¥BUric acid 11.3 mg/dL¡AÂå®v­ì¥ý¶}¥ßbenzbromarone 50mg QD¡A¦]¯f¤HµÇ¥\¯à®teGFR 3.4 mL/min/1.73m2¥B¤w¬~µÇ¡A¬G¤£«Øij¨Ï¥Î¡A½ÐÂå®v§ï¬°febuxostat 40mg QD¡C



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1.Benzbromarone: Drug information. UpToDate Lexidrug. Waltham, MA.
http://www.uptodate.com (Accessed on July 16, 2024.)
2.Febuxostat: Drug information. UpToDate. Waltham, MA.
http://www.uptodate.com (Accessed on July 16, 2024.)


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