◎ 文/許乙婷 (藥學生)、林聖凰 (指導藥師)
目前國內核准用於減肥的GLP-1 RA僅有Saxenda® 和 Wegovy®,自費價格雖動輒萬元起跳,想要減肥的民眾仍趨之若鶩,甚至曾有自費購買其他非減重適應症之GLP-1
RA 注射藥品用於減重之案例。111年底GLP-1 RA曾因生產問題導致全球供應不足,造成GLP-1 RA
皮下注射藥品供不應求,國內受影響糖尿病友高達25萬人,食藥署提醒醫師及醫療機構,該類藥品應優先用於第二型糖尿病治療。同時提醒民眾,減重若有用藥需求仍應經醫師評估,優先使用核准於控制體重之藥品,且應調整生活型態,配合飲食控制,搭配規律運動,才是維持身體健康與良好體態的長遠之計。
參考資料:
1. Obesity in adults: Drug therapy. UpToDate®, Accessed March 12,
2023, from the web : https://www.uptodate.com/contents/obesity-in-adults-drug-therapy?source=mostViewed_widget.
2. Pi-Sunyer X, Astrup A, Fujioka K, et al. A Randomized, Controlled
Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med.
2015;373:11-22.
3. Rubino D, Abrahamsson N, Davies M, et al. Effect of Continued
Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss
Maintenance in Adults With Overweight or Obesity: The STEP 4
Randomized Clinical Trial. JAMA. 2021;325:1414-25.
4. Wilding JPH, Batterham RL, Davies M, et al. Weight regain and
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(本文作者為國立陽明交通大學藥學生;指導藥師為臺北榮民總醫院藥學部臨床藥師 /
陽明交通大學藥學所臨床藥學組碩士)
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