◎文/王怡晴
疑義說明:
⑴此病人本身患有小細胞肺癌,因雙測肺炎合併呼吸衰竭入加護病房,影像學及臨床症狀強烈懷疑PJP感染,使用TMP-SMX進行治療,但開立處方為Bacide®
tab 400 mg (TMP 80 mg-SMX 400 mg) 2# NOON,為預防PJP之劑量。
⑵TMP-SMX治療之療程為TMP 15-20 mg/kg/day+SMX 75-100
mg/kg/day口服或IV,分3-4次給藥,21天,依此病人65 kg,劑量應調整為Bacide® tab 400 mg 3# Q6H
檢驗項目參考值:
BUN (blood urea nitrogen): 7-20 mg/dL; SCr (serum creatinine): male:
0.7-1.5 mg/dL; female: 0.5-1.2 mg/dL; CCr (creatinine clearance
rate): >60 mL/min; ALT (alanine aminotransferase): 0-40 U/L;LDH
(lactate dehydrogenase): male: 135-225 U/L; female: 135-214 U/L; CRP
(C-reactive protein): <0.5 mg/dL
參考資料:
1.台灣肺炎診治指引 (2018年)
2.Charles F (2023). Treatment and prevention of Pneumocystis
pneumonia in patients without HIV. Uptodate, retrieved April 20,
2023, from https://www.uptodate.com/contents/treatment-and-prevention-of-pneumocystis-pneumonia-in-patients-without-hiv/
(本文作者為臺北榮民總醫院藥學部臨床藥師 / 陽明大學藥理所碩士)
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