臨床藥學大觀園

《論藥之道》

抗血小板藥於經皮冠狀動脈介入治療之負載劑量(下)

◎文╱陳柏瑋
處方評估
3. 疑義說明
(1)	此病人因冠心病入院欲放置支架，醫師開立4顆aspirin 100 mg及3顆clopidogrel 75 mg。
(2)	依建議負載劑量，應開立3顆aspirin 100 mg及4顆clopidogrel 75 mg。
檢驗項目參考值：
BUN (blood urea nitrogen): 7-20 mg/dL; SCr (serum creatinine): male: 0.7-1.5 mg/dL; female: 0.5-1.2 mg/dL; CCr (Creatinine clearance rate): >60 mL/min; ALT (alanine aminotransferase): 0-40 U/L; AST (aspartate aminotransferase): 5-45 U/L



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參考資料
1.	Jean-Philippe Collet, Holger Thiele, Emanuele Barbato, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 2021;42:1289-1367.
2.	Shigeru Saito, Takaaki Isshiki, Takeshi Kimura, et al. Efficacy and safety of adjusted-dose prasugrel compared with clopidogrel in Japanese patients with acute coronary syndrome: the PRASFIT-ACS study. Circ J 2014;78:1684-92.

（本文作者為臺北榮民總醫院藥學部臨床藥師 / 陽明大學藥理所碩士）